Endocrine Abstracts

Background: Continuous subcutaneous insulin infusion (CSII), alongside multiple daily injections (MDI) are the most frequent therapeutic of type 1 Diabetes Mellitus (DM). We aimed to evaluate the effects of the transition from MDI to CSII in the treatment of type 1 DM.Patients and methods: This retrospective longitudinal study analysed patients that received treatment with CSII from 2006 to 2014. Our sample had 85 patients, 35 male (41.2%) and 50 female ...

Introduction: The incidence of glucose metabolism alterations during the follow-up of surgically treated insulinomas is largely unknown. Our aim was to evaluate the incidence, and the clinical characteristics, of diabetes and prediabetes in this population.Methods: We retrospectively analyzed the cases diagnosed as insulinomas in a Central Hospital in Portugal in the period between January 1980 and December 2015.Results: We identif...

Introduction: Insulinomas are pancreatic endocrine tumors originating in the beta cells, characterized by hypoglycemia resulting from insulin hypersecretion.Objectives: To characterize the demography, the clinical features, imagiological findings and pathological evaluation of the cases of insulinomas identified in the previous 35 years at São João Hospital.Methods: We retrospectively analyzed the cases diagnosed as insul...

Background: Diabetes is an important risk factor for major adverse cardiovascular events (MACE). Although the increased risk for MACE is well known, the impact on the in-hospital outcomes remains incompletely understood. Our aim was to evaluate the interrelation between diabetes and MACE in a central hospital in the North of Portugal between 2009 and 2015.Methods: We evaluated retrospectively the hospitalizations due to MACE including stroke or transient...

Introduction: Adipose tissue disturbances (lipodystrophy and obesity) are prevalent in patients infected with HIV. Our aims were to evaluate the prevalence of obesity and the association with lipodystrophy, the effect of gender, age, viral replication, duration of disease and cART in a population of HIV patients under cART.Methods: In this retrospective study, 580 patients were included. The characteristics of the population are presented through percent...

Aim: The aim of this study was to evaluate the association between thyroid function in Graves’ disease (GD) with high-sensitivity C-reactive protein (hs-CRP), lipid profile, homocysteine, folate, vitamin B12 and insulin resistance.Methods: We performed a cross-sectional of 104 patients with recently diagnosed GD. All participants were in the first cycle of treatment with methimazole. We collected demographic information, body mass indexes (BMI), lab...

Introduction: Obese patients are at an increased risk of develop nonalcoholic fatty liver disease. Evidence supports that bariatric surgery might have an important impact on hepatic profile in obese adults. Literature suggests that bariatric surgery in adolescents might decrease the prevalence of some comorbidities, but information about its impact on liver profile and steatosis and fibrosis risk remains scarce.Aim: To evaluate the impact of bariatric su...

Introduction: Obesity is a complex multifactorial disease and its prevalence in pediatric age has increased. Obesity prejudices the individual metabolic profile due to the adipotoxicity involved in this condition. Bariatric surgery improves the weight of obese patients along with metabolic comorbidities, being today one of the most effective treatments for obesity. Time of exposure to adipotoxicity appears to be an important risk factor for the development of metabolic complic...

Background: Children who were born small for gestational age (SGA) and who do not have adequate catch-up growth until 4 years old have indication for treatment with recombinant human growth hormone (rhGH). The metabolic consequences of this treatment are relatively unknown. Objective: To evaluate the effect of rhGH treatment on insulin sensitivity and lipid profile.Materials and methods: A retrospective observational study of child...

Introduction: Primary acinic cell carcinoma (ACC) is an uncommon salivary gland (SG) tumor, making up 1–3% of all SG neoplasms, more frequent in women, at 40–60 year old. The cause is still unknown and the only well-established risk factor is ionizing radiation. ACC metastasize in 10–15% of the cases, 35% tends to recur and the rate of disease-associated death is about 16%. Surgical resection is the mainstay treatment, but radiation therapy may be used in some c...